Weight & metabolic

Retatrutide

LY3437943

dose range

2–12 mg

frequency

1×/wk · subq

cycle

Continuous

half-life

~6 days

vials

10 · 15 · 20 · 30 · 40 · 50 · 60 mg

recon @ fridge

56 days

Receptor logic

GIP / GLP-1 / glucagon tri-agonist

At ~1 mg/wk: GIPR 47–57% occupancy, GLP-1R 7–8% (appetite), GCGR drives modest hepatic fat-oxidation. The first 1–2 mg does most of the metabolic work.

What to watch

Population caveat: trial cohort was BMI 37, 109 kg, sedentary. Lighter/leaner = higher exposure per kg → start lower, titrate slower.

Stacks with

No proven add-on stack. Tesamorelin is discussed as an experimental visceral-fat/body-composition adjunct, but efficiency is better framed as slow titration, lowest effective dose, protein, resistance training, and avoiding vial waste.

Stability

Lyophilized

Frozen · as-shipped, sealed

12+ months

Reconstituted

Refrigerated · 2–8°C, working state

56 days

Reconstituted

Room · avoid; degrades fast

14 days

Vial sizes · source the peptide

RETA-10 · 10mgBuy · Vialogy →