Weight & metabolic
Retatrutide
LY3437943
dose range
1–12 mg
frequency
1×/wk · subq
cycle
Continuous
half-life
~6 days
vials
5 · 10 · 15 mg
recon @ fridge
56 days
Receptor logic
GIP / GLP-1 / glucagon tri-agonist
At ~1 mg/wk: GIPR 47–57% occupancy, GLP-1R 7–8% (appetite), GCGR drives modest hepatic fat-oxidation. The first 1–2 mg does most of the metabolic work.
What to watch
Population caveat: trial cohort was BMI 37, 109 kg, sedentary. Lighter/leaner = higher exposure per kg → start lower, titrate slower.
Stacks with
Standalone recomp. Pair with adequate protein + resistance training to bias loss toward fat.
Stability
Lyophilized
Frozen · as-shipped, sealed
12+ months
Reconstituted
Refrigerated · 2–8°C, working state
56 days
Reconstituted
Room · avoid; degrades fast
14 days
Vial sizes · source the peptide
RETA-5 · 5mgBuy · Vialogy →
RETA-10 · 10mgBuy · Vialogy →
RETA-15 · 15mgBuy · Vialogy →
Bacteriostatic water
you'll need this to reconstitute
Orders are saved to your account, so reorder reminders know what you bought.
Citations
Jastreboff 2023 · NEJM 389:514 · NCT04881760
Coskun 2022 · Cell Metab · Phase 1 SAD